A MULTISTAGE PLASMODIUM CRL4WIG1 UBIQUITIN LIGASE IS CRITICAL FOR THE FORMATION OF FUNCTIONAL MICROTUBULE ORGANIZATION CENTERS IN MICROGAMETOCYTES

A multistage Plasmodium CRL4WIG1 ubiquitin ligase is critical for the formation of functional microtubule organization centers in microgametocytes

ABSTRACT Malaria is a mosquito-borne infectious disease caused by unicellular eukaryotic parasites of the Plasmodium genus.Protein ubiquitination by E3 ligases is a critical post-translational modification required for various cellular processes during the lifecycle of Plasmodium parasites.However, little is known about the repertoire and function

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Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities.Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities.Electron transfer in POR occurs from NADH to FAD to F

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EFFECT OF POLYETHYLENE GLYCOL SUPPLEMENTATION ON IN VITRO NITROGEN DIGESTIBILITY OF LEUCAENA SHRUB LEGUM SPECIES AND SIGNAL GRASS (BRACHIARIA DECUMBENS)

SUMMARY An in vitro study was conducted to investigate the effect of polyethylene glycol (PEG) supplementation on in vitro nitrogen digestibility in shrub species legume and grass.The nitrogen digestibility of varied correspondingly to their nutrient and condensed tannin (CT) content.Leuceana species with a lower CT tended to have higher in vitro n

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GasBotty: Multi-Metric Extraction in the Wild

The lived environment, particularly when proximal to roadways, is filled with multi-digit and multi-numbered values corresponding to advertised commodities.The reliable detection of single multi-digit values from natural imagery has been widely studied through the last decade (e.g.Street View House Numbers [SVHN]); however, extraction and assignmen

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Vehicle routing for a mid-day meal delivery distribution system

This paper considers the distribution system of a school feeding program (mid-day meals), wherein a set of delivery vehicles Other switches transfer cooked food from a kitchen facility to various schools within a specified delivery deadline.The food is required to be delivered before the lunch period, which is consistent across all the schools.A de

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